Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase
نویسندگان
چکیده
منابع مشابه
A Novel Benzoxazole Inhibitor of Dengue Virus Replication that 1 Targets the NS 3 Helicase
A Novel Benzoxazole Inhibitor of Dengue Virus Replication that 1 Targets the NS3 Helicase 2 3 Chelsea M. Byrd*, Douglas W. Grosenbach, Aklile Berhanu, Dongcheng Dai, 4 Kevin F. Jones, Kara B. Cardwell, Christine Schneider,Guang Yang, 5 Shanthakumar Tyavanagimatt, Chris Harver, Kristin A. Wineinger, Jessica Page, 6 Eric Stavale, Melialani A. Stone, Kathleen P. Fuller, Candace Lovejoy, 7 Janet M....
متن کاملA novel inhibitor of dengue virus replication that targets the capsid protein.
Dengue viruses (DENV) infect 50 to 100 million people worldwide per year, of which 500,000 develop severe life-threatening disease. This mosquito-borne illness is endemic in most tropical and subtropical countries and has spread significantly over the last decade. While there are several promising vaccine candidates in clinical trials, there are currently no approved vaccines or therapeutics av...
متن کاملNS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication
The protein-RNA interactions within the flavivirus replication complex (RC) are not fully understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase bound to the conserved 5' genomic RNA 5'-AGUUGUUAGUCU-3' reveals that D290 and R538 make specific interactions with G2 and G5 bases respectively. We show that single-stranded 12-mer RNA stimulates ATPase activity of NS...
متن کاملNovel ATP-Independent RNA Annealing Activity of the Dengue Virus NS3 Helicase
The flavivirus nonstructural protein 3 (NS3) bears multiple enzymatic activities and represents an attractive target for antiviral intervention. NS3 contains the viral serine protease at the N-terminus and ATPase, RTPase, and helicase activities at the C-terminus. These activities are essential for viral replication; however, the biological role of RNA remodeling by NS3 helicase during the vira...
متن کاملIdentification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication.
Dengue virus (DENV) is an important human arthropod-borne virus with a major impact on public health. Nevertheless, a licensed vaccine or specific treatment is still lacking. We therefore screened the NIH Clinical Collection (NCC), a library of drug-like small molecules, for inhibitors of DENV replication using a cell line that contains a stably replicating DENV serotype 2 (DENV2) subgenomic re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2013
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02251-12